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Journal Articles

PprI: A General switch responsible for extreme radioresistance of ${it Deinococcus radiodurans}$

Hua, Y.*; Narumi, Issei; Gao, G.*; Tian, B.*; Sato, Katsuya; Kitayama, Shigeru; Shen, B.*

Biochemical and Biophysical Research Communications, 306(2), p.354 - 360, 2003/06

https://doi.org/10.1016/S0006-291X(03)00965-3
 Times Cited Count：152 Percentile：95.76(Biochemistry & Molecular Biology)

We have identified a unique deinococcal gene, ${it pprI}$, as a general switch for downstream DNA repair and protection pathways, from a natural mutant, in which ${it pprI}$ is disrupted by a transposon. Complete functional disruption of the gene in wild-type leads to dramatic sensitivity to ionizing radiation. Radioresistance of the disruptant could be fully restored by complementation with ${it pprI}$. In response to radiation stress, PprI can significantly and specifically induce the gene expression of ${it recA}$ and ${it pprA}$ and enhance the enzyme activities of catalases. These results strongly suggest that PprI plays a crucial role in regulating multiple DNA repair and protection pathways in response to radiation stress.

Journal Articles

Effect of hydration on the induction of strand breaks and base lesions in plasmid DNA films by $$gamma$$-radiation

Yokoya, Akinari; Cunniffe, S. M. T.*; O'Neill, P.*

Journal of the American Chemical Society, 124(30), p.8859 - 8866, 2002/07

https://doi.org/10.1021/ja025744m
 Times Cited Count：87 Percentile：87.69(Chemistry, Multidisciplinary)

no abstracts in English

Journal Articles

Molecular dynamics simulation of 7,8-dihydro-8-oxoguanine DNA

Ishida, Hisashi

Journal of Biomolecular Structure and Dynamics, 19(5), p.839 - 851, 2002/05

https://doi.org/10.1080/07391102.2002.10506788
 Times Cited Count：11 Percentile：26.27(Biochemistry & Molecular Biology)

no abstracts in English

Journal Articles

A Novel protein that recognizes DNA strand break

Narumi, Issei; Sato, Katsuya; Kikuchi, Masahiro

JAERI-Conf 2002-005, p.158 - 171, 2002/03

https://jopss.jaea.go.jp/pdfdata/JAERI-Conf-2002-005.pdf

${it Deinococcus radiodurans}$ is characterized by its extraordinary resistance to the lethal and mutagenic effects of ionizing and ultraviolet irradiations and many other DNA-damaging agents. By analyzing a DNA repair-deficient mutant strain, we discovered that a novel protein participates in the extreme radiation resistance of ${it D. radiodurans}$. The protein (designated PprA for promoting prominent repair) can recognize DNA strand breaks. Further, PprA would protect irradiation-damaged DNA from exonuclease activity and consequent degradation and thereby ensure DNA repair processes could function. Beside DNA-binding ability, PprA can promote the activities of DNA ligase and RecA, suggesting that PprA functions as a DNA repair-promoting protein to potentiate the effectiveness of DNA repair. These properties enable PprA to use the widespread application ${it in vivo}$ and ${it in vitro}$.

Journal Articles

Recognition of DNA damage and induction of repair proteins in ${it Deinococcus radiodurans}$

Sato, Katsuya; Kikuchi, Masahiro; Narumi, Issei

JAERI-Conf 2002-005, p.172 - 184, 2002/03

https://jopss.jaea.go.jp/pdfdata/JAERI-Conf-2002-005.pdf

${it Deinococcus radiodurans possesses}$ a DNA damage response mechanism. However, the damage response is poorly understood in ${it D. radiodurans}$. By investigating the function of deinococcal proteins, we found that, unlike in ${it E. coli}$, LexA is not involved in the regulation of RecA in ${it D. radiodurans}$. This, in turn, led us to speculate that ${it D. radiodurans}$ has an alternative DNA damage response mechanism with which to control ${it recA}$ expression. Recently, we discovered that a novel protein regulates the expression of ${it recA}$ gene. The novel regulatory protein (designated as PprI) also control the induction of ${it pprA}$ gene following $$gamma$$ irradiation. Thus, ${it D. radiodurans}$ possesses unique mechanisms of DNA damage recognition and repair gene induction.

Journal Articles

The LexA protein from ${it Deinococcus radiodurans}$ is not involved in RecA induction following $$gamma$$ irradiation

Narumi, Issei; Sato, Katsuya; Kikuchi, Masahiro; Funayama, Tomoo; Yanagisawa, Tadashi*; Kobayashi, Yasuhiko; Watanabe, Hiroshi; Yamamoto, Kazuo

Journal of Bacteriology, 183(23), p.6951 - 6956, 2001/12

https://doi.org/10.1128/JB.183.23.6951-6956.2001
 Times Cited Count：91 Percentile：83.71(Microbiology)

The involvement of LexA in induction of RecA was investigated in ${it Deinococcus radiodurans}$. As in the wild-type strain, an increase in RecA protein synthesis following $$gamma$$ irradiation was detected in a ${it lexA}$ disruptant, indicating that LexA is not involved in the induction of RecA in ${it D. radiodurans}$.

Journal Articles

Molecular dynamics simulation of damaged DNA's and repair enzymes

Pinak, M.

Radiation Risk Assessment Workshop Proceedings, p.30 - 39, 2001/00

no abstracts in English

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